Grant
MICHIGAN STATE UNIVERSITY
$335,924
Department of Health and Human Services
Award ID
R35GM162132
Action Date
2026-04-01
Fiscal Year
FY 2026
Award Type
Grant
Place of Performance
EAST LANSING, Michigan
Period of Performance
2026-04-01 → 2031-03-31
Funding Agency
Department of Health and Human Services
Description
ENGINEERING RADICAL ENZYMES FOR ASYMMETRIC OLEFIN HYDROALKYLATION - PROJECT SUMMARY: THE SYNTHESIS OF BIOLOGICALLY ACTIVE MOLECULES THROUGH SELECTIVE C–C BOND-FORMING REACTIONS IS CENTRAL TO THE DISCOVERY OF NEW THERAPEUTICS. THOUGH FORGING C–C BONDS IS OFTEN MORE CHALLENGING AT C(SP3)-CENTERS THAN C(SP2)-CENTERS, ESPECIALLY WHEN NEW STEREOCENTERS EMERGE, CLINICAL SUCCESS IS CORRELATED WITH SP3-RICHNESS. CONSEQUENTLY, DEVELOPING NEW METHODS TO RAPIDLY GENERATE COMPLEX, SP3-RICH COMPOUNDS FROM SI
Recipient
Name
MICHIGAN STATE UNIVERSITY
State
MI
UEI
R28EKN92ZTZ9