Grant
THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
$363,191
Department of Health and Human Services
Award ID
R35GM161559
Action Date
2026-04-01
Fiscal Year
FY 2026
Award Type
Grant
Place of Performance
PHILADELPHIA, Pennsylvania
Period of Performance
2026-04-01 → 2031-01-31
Funding Agency
Department of Health and Human Services
Description
THE ROLE OF NON-CANONICAL NUCLEIC ACID STRUCTURES IN GENOME REGULATION - PROJECT SUMMARY NUCLEAR PROCESSES SUCH AS TRANSCRIPTION, REPLICATION, AND REPAIR DISRUPT THE DOUBLE STRANDED NATURE OF DNA TO RESULT IN THE FORMATION OF NON-CANONICAL STRUCTURES, THE MOST PREVALENT BEING R-LOOPS AND G-QUADRUPLEXES (G4S). R-LOOPS ARE THREE-STRANDED NUCLEIC ACID STRUCTURES, WHICH OCCUR CO-TRANSCRIPTIONALLY AND COMPRISE AN RNA-DNA HYBRID AND A DISPLACED SINGLE STRAND OF DNA. THE DISPLACED SSDNA CAN FORM G4S IF
Recipient
Name
THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
State
PA
UEI
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