Grant
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE
$478,621
Department of Health and Human Services
Award ID
R35GM161389
Action Date
2026-04-01
Fiscal Year
FY 2026
Award Type
Grant
Place of Performance
PHILADELPHIA, Pennsylvania
Period of Performance
2026-04-01 → 2031-03-31
Funding Agency
Department of Health and Human Services
Description
EPIGENETIC REGULATION AND FUNCTION OF IMPRINTED GENES - ABSTRACT A FEW HUNDRED GENES IN MAMMALS ARE REGULATED BY GENOMIC IMPRINTING. THESE GENES ARE EPIGENETICALLY MARKED AND EXHIBIT PARENTAL-OF-ORIGIN-SPECIFIC GENE EXPRESSION. IMPRINTING PLAYS A ROLE IN THE TRANSMISSION OF A NUMBER OF HUMAN DISORDERS, INCLUDING BECKWITH-WIEDEMANN SYNDROME AND SILVER-RUSSELL SYNDROME, WHERE THE SEX OF THE PARENT TRANSMITTING THE AFFECTED GENE(S) DETERMINES WHETHER OFFSPRING WILL BE IMPACTED. ADDITIONALLY, IMPRIN
Recipient
Name
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE
State
PA
UEI
GM1XX56LEP58