Grant
WAKE FOREST UNIVERSITY HEALTH SCIENCES
$622,071
Department of Health and Human Services
Award ID
R01CA301353
Action Date
2026-05-01
Fiscal Year
FY 2026
Award Type
Grant
Place of Performance
WINSTON SALEM, North Carolina
Period of Performance
2026-05-01 → 2031-04-30
Funding Agency
Department of Health and Human Services
Description
MICROBIOME-METABOLOME SIGNALING INTERACTIONS REDUCE OBESITY-MEDIATED BREAST CANCER RISK - PROJECT SUMMARY/ABSTRACT: DIET IS A MAIN DETERMINANT OF GUT MICROBIAL DIVERSITY. OUR GROUP DEMONSTRATED DIET SHIFTS BREAST MICROBIOME POPULATIONS. IN A NON-HUMAN PRIMATE (NHP) MODEL, OUR GROUP SHOWED THAT CONSUMPTION OF A WESTERN OR MEDITERRANEAN DIET MODULATED BREAST TISSUE MICROBIOTA AND MICROBIAL-DERIVED METABOLITE PROFILES. THE SHIFT IN THE BACTERIAL-PRODUCED METABOLOME WAS SPECIFIC TO BREAST TISSUE AND
Recipient
Name
WAKE FOREST UNIVERSITY HEALTH SCIENCES
State
NC
UEI
SN7KD2UK7GC5