BRIGHAM & WOMENS HOSPITAL INC

Description

TARGETED GENE DELIVERY TO NOCICEPTORS - PROJECT SUMMARY/ABSTRACT CHRONIC PAIN PRESENTS AS A SIGNIFICANT SOURCE OF DISABILITY FOR LARGE NUMBERS OF PEOPLE IN THE U.S. OF THESE PATIENTS, MANY SUFFER FROM CHRONIC CRANIOFACIAL AND DENTAL PAIN WHICH IS CAUSED BY THE CONTINUOUS ACTIVATION OF TRIGEMINAL PAIN SENSING NEURONS (NOCICEPTORS). CONDITIONS LIKE TRIGEMINAL NEURALGIA, FOR INSTANCE, ARE ASSOCIATED WITH SIGNIFICANT MORBIDITY AND HIGHER SUICIDE RATES. IN ADDITION, THE CURRENT TREATMENTS FOR SUCH PE

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