Grant
PRESIDENT AND FELLOWS OF HARVARD COLLEGE
$37,704
Department of Health and Human Services
Award ID
F31DK143670
Action Date
2026-09-13
Fiscal Year
FY 2026
Award Type
Grant
Place of Performance
BOSTON, Massachusetts
Period of Performance
2026-09-13 → 2027-09-12
Funding Agency
Department of Health and Human Services
Description
UNDERSTANDING THE ROLE AND REGULATION OF EPITHELIAL KETOGENESIS IN THE COLON - ABSTRACT INTESTINAL STEM CELLS (ISCS) PLAY PIVOTAL ROLES IN INTESTINAL EPITHELIUM RENEWAL DURING HOMEOSTASIS AND AFTER INJURY. THE METABOLIC DEMANDS FACED BY ISCS REQUIRE HIGH MITOCHONDRIAL OXIDATIVE PHOSPHORYLATION (OXPHOS) ACTIVITY COMPARED TO OTHER DIFFERENTIATED CELLS. ISCS’ MITOCHONDRIAL DYSFUNCTION HAS BEEN IMPLICATED IN THE ETIOPATHOGENESIS OF INTESTINAL BOWEL DISEASES (IBD), WHICH AFFLICTS OVER 2 MILLION PEOPL
Recipient
Name
PRESIDENT AND FELLOWS OF HARVARD COLLEGE
State
MA
UEI
JDLVAVGYJQ21