REGENTS OF THE UNIVERSITY OF MICHIGAN

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ERI: ENGINEERING PERIVASCULAR MICROPHYSIOLOGICAL SYSTEMS TO DISCOVER HYDRODYNAMIC SIGNATURES OF NEURODEGENERATION -INCURABLE BRAIN DISEASES, INCLUDING ALZHEIMER?S, PARKINSON?S, AND AMYOTROPHIC LATERAL SCLEROSIS (ALS), ARE CAUSED BY AN UNHEALTHY BUILDUP OF NORMAL BRAIN WASTE PROTEINS. RECENT RESEARCH HAS SHOWN THAT THE BRAIN USES CEREBROSPINAL FLUID (CSF), A CLEAR FLUID THAT SURROUNDS AND CUSHIONS THE BRAIN, TO FLUSH OUT THESE WASTES. WASTE PROTEINS OFTEN BUILD UP AROUND ARTERIES, WHERE THE FLUID

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